Inclusion of Citrullus colocynthis Seed Extract into Diets Induced a Hypolipidemic Effect and Improved Layer Performance

Citrullus colocynthis (CC) has been known as a natural medicinal plant with wide biological activities, including antioxidant, anti-inflammatory, and antilipidemic effects. The aim of this study was to investigate the effect inclusion ethanolic extract CC seeds (ECCs) into layer diets on lipid profile, stress indicators, physiological productive performance laying hens. A total 216 forty-week-old commercial Hy-Line brown hens were randomly assigned four equal groups (3 birds × 18 replicates per group) that received basal diet supplemented 0, 0.5, 1.0, 2.0 g/kg ECCs for 12 consecutive weeks. first group served control. results showed at 1.0 significantly (p < 0.05) improved compared other groups. In addition, indicators examined in hens, peroxidation (malondialdehyde (MDA)), corticosterone hormone (CORT), tumor necrosis factor alpha (TNF?), heat shock protein 70 (HSP70), alleviated after three levels control group. Furthermore, all ECC induced significant reduction plasma triglyceride (TG) cholesterol (CH) plasma, liver, egg yolk, whereas highest obtained ECCs. Particularly important, high linear correlation (R2 = 0.60–0.79) observed between increasing doses MDA, liver CH, yolk CH concentrations weight, feed intake, conversion ratio; moreover, extremely 0.80–0.100) level TG, low-density lipoprotein high-density CORT. These indicated dietary supplementation could be considered successful nutritional approach producing healthier, lower-cholesterol eggs consumers, addition enhancing by alleviating intensive production.